“Innovating Health” Webinar – Prof Samir Mitragotri
Cellular Hitchhiking for Cancer Chemo and Immunotherapy
9 am – 10:15 am, Tuesday, 12 January 2021 (Singapore)
8 pm – 9:15 pm, Monday, 11 January 2021 (Boston)
Prof Samir Mitragotri
Hiller Professor of Bioengineering, Hansjorg Wyss Professor of Biological Inspired Engineering, Harvard University.
Nanoparticle-based drug delivery systems are widely studied to improve the biological outcome of chemo and immunotherapy. However, poor vascular circulation, limited targeting and the inability to negotiate many biological barriers impede their clinical translation. Biology has provided many examples of successful “carriers” in the form of circulatory cells, which routinely overcome the hurdles faced by synthetic nanoparticle systems. For this reason, our laboratory has engineered blood-cell inspired drug delivery systems that take advantage of the abilities of red blood cells and macrophages as circulatory cells. We explored the “cellular hitchhiking” mechanism by combining synthetic particles with circulatory cells to alter the synthetic particles’ in vivo abilities drastically. This talk will provide an overview of the principles and two examples of hitchhiking-based cancer immunotherapy.
Samir Mitragotri is the Hiller Professor of Bioengineering and Wyss Professor of Biologically Inspired Engineering at Harvard University. His research has provided new insights into biological barriers of skin, blood-brain barrier, immune clearance and gastrointestinal tract, among others. His research has also led to new methods of transdermal, oral, and targeted drug delivery systems. He is an author of over 300 publications and is a Thomson Reuters Highly Cited Researcher. Prof Mitragotri is an inventor on over 180 patent/patent applications. He is an elected member of the National Academy of Engineering, National Academy of Medicine and National Academy of Inventors. He is a foreign member of Indian National Academy of Engineering. He is also an elected fellow of AAAS, CRS, BMES, AIMBE, and AAPS. He received BS in Chemical Engineering from the Institute of Chemical Technology, India and PhD in Chemical Engineering from the Massachusetts Institute of Technology. He is the Editor-in-Chief of AIChE’s and SBE’s journal Bioengineering and Translational Medicine.
Register the webinar here: https://bit.ly/3hBENKp
Download the poster here [pdf]