NUS researchers develop revolutionary technology to unravel complex protein interactions that could transform cancer diagnostics
- September 30, 2024
 |
Tandem Elongation of Templated DNA Repeats for Analysis of Interacting Proteins (TETRIS) is an innovative cancer diagnostic technique developed by iHealthtech Principal Investigators, Assoc Prof Shao Huilin and Brian Lim. TETRIS offers significant advancements over existing diagnostic methods, particularly in its ability to rapidly and accurately diagnose cancer types within just a few hours. Additionally, it can detect complex, higher-order interactions between cancer cells and various cellular proteins. Using biopsies from human breast cancer tissue, the team demonstrated that the method can accurately identify cancer subtypes and reveal cancer aggressiveness.
This capability to map intricate protein interactions—especially those involving multiple proteins—provides deeper insights into biological processes, disease mechanisms, and drug targeting strategies. Ultimately, TETRIS holds great potential for advancing precision medicine and improving cancer therapies.
Their study was published in the peer-reviewed scientific journal Nature Biomedical Engineering, with two research fellows, Dr Liu Yu and Dr Noah Sundah, as first authors.
Related News:
