NUS researchers develop an innovative and flexible method to study immune cell capabilities
- December 18, 2023
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Our bodies serve as battlegrounds where the immune system quietly wages war against infections and cancer cells, safeguarding our health. While recent advancements in cell-based immunotherapy, harnessing cells like T-cells and natural killer cells, offer promise in treating diseases, particularly cancer, scientists grapple with the challenge of directly observing these cells’ actions.
In an innovative approach to cellular forensics, iHealthtech Assistant Professor Cheow Lih Feng, Dr Luah Yen Hoon and Dr Wu Tongjin introduce PAINTkiller (‘proximity affinity intracellular-transfer identification of killer cells’). This method aims to visualise the ‘crime scenes’ where cytotoxic cells eliminate infections and cancer cells, potentially unravelling crucial insights into the mysteries of health and disease.
The team’s methodology excels in selectively identifying killer cells proficiently in eliminating a target cell. This promises to be a valuable tool, significantly elevating the quality and functionality of the ultimate therapeutic product.
Their work was published in Nature Biomedical Engineering:
Identification, sorting and profiling of functional killer cells via the capture of fluorescent target-cell lysate
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